Antibiotic resistance gene analysis

TECHNOLOGY SERVICES

Product introduction
Common problem
Classic case
Result display

Product introduction

Which ARGs are in the sample?
What is the abundance of ARGs?
Which strains do ARGs come from?

Which movable elements carry ARGs?

Where are ARGslocated? Chromosome or Plasmid? What are the differences in ARGs
different treatments and different backgrounds?

Antibiotic resistance genes (ARGs) are a new type of persistent environmental pollutants. Plasmids, integrons, and transposons that carry ARGs in bacteria can undergo horizontal gene transfer between strains. long-term existence in the environment. ^[1]complete DNA sequence was obtained by Nanopore sequencing technology, and the distribution and sequence of ARGs in environmental microorganisms were studied through bioinformatics analysis, so as to further explore their functions and mechanisms.

Obtained after analysis —

the identification results of ARGs in the target samples
ARGs abundance in each sample
Species information of ARGs annotated
antibiotic resistance gene clusters
antibiotic resistance gene location

[1]Knapp CW , Engemann CA , Hanson ML , et al. Indirect Evidence of Transposon-Mediated Selection of Antibiotic Resistance Genes in Aquatic Systems at Low-Level Oxytetracycline Exposures[J]. Environmental ence & Technology, 2008, 42(14) : 5348-5353.

Paper recommendation

Che Y , Xia Y , Liu L , et al., Mobile antibiotic resistome in wastewater treatment plants revealed by Nanopore metagenomic sequencing[J]. Microbiome, 2019, 7(1).
Sukhum K V , Diorio-Toth L , Dantas G. Genomic and Metagenomic Approaches for Predictive Surveillance of Emerging Pathogens and Antibiotic Resistance[J]. Clinical Pharmacology & Therapeutics, 2019, 106(3).
Leggett et al., Rapid MinION profiling of preterm microbiota and antimicrobial-resistant pathogens[J]. Nature Microbiology. 2019.