Abstract While splicing changes caused by somatic mutations in SF3B1 are known, identifying fulllength isoform changes may better elucidate the functional consequences of these mutations. We report nanopore sequencing of full-length cDNA fr ...

Abstract Regulation of transcript structure generates transcript diversity and plays an important role in human disease. The advent of long-read sequencing technologies offers the opportunity to study the role of genetic variation in transc ...

Abstract N6-methyladenosine (m6A) mRNA modification represents the mostwidespread form of internal modifications in eukaryotic mRNAs. In the modelplant Arabidopsis thaliana, those known methyltransferases mainly depositm6A at their target t ...

Abstract Sequence features of genes and their flanking regulatory regions are determinants of RNA transcript isoform expression and have been used as context-independent plug-and-play modules in synthetic biology. However, genetic contextin ...

葡萄酒的经济和文化价值受不同的地理位置影响，通常被认为是风土。本研究结合宏基因组学和扫描电镜技术，研究了冻融胁迫和葡萄状态的关系，探索了维达尔白葡萄表面微真核菌群 ...

抗生素耐药性的传播是一个日益严重的全球公共卫生威胁，而污水处理厂（WWTPs）富含微生物的活性污泥环境可能是抗生素耐药性基因（ARG）传播的重要因素之一。本研究通过应用长读 ...

急性期后COVID-19综合征（PACS）定义为SARS-CoV-2病毒清除4周后至少出现一种持续症状。多达四分之三的新冠病毒病患者在康复后6个月内出现了至少一种症状，并且经常出现多系统症状，包 ...

文章简介： 稗属（ Echinochloa spp）物种是稻田生态系统中最有害、最常见的杂草。同时，至少有两个稗属物种被驯化为黍类作物。为了进一步了解推动稗属物种向杂草与作物演化的基因 ...

简介： 最大的活啮齿动物水豚可以通过微生物共生机制有效地解聚和利用木质纤维素生物质，但其机制目前还不清晰。本文利用宏基因组结合代谢组、宏转录组等技术研究，阐明了将膳 ...

长链未解码转录亚型（LUTI）是一类非规范mRNA，通过转录和翻译抑制的联合作用下调基因表达。虽然单基因研究揭示了LUTI抑制的重要方面，但这些特征如何在全基因组范围内影响基因调 ...