Product introduction
DNA methylation, a form of epigenetic modification that does not alter the DNA sequence, is currently the most studied form of DNA methylation, mainly for 6mA and 5mC. Nanopore sequencing detects both 6mA and 5mC directly by sequencing without the need for bisulfate conversion or immunoprecipitation enrichment experiments.
Advantages of Nanopore DNA methylation
Sequence distribution of methylation sites
Methylation levels in different regions
Genetic Imprinting（Gigante et al, 2019）
Characteristics of various methylation detection techniques（Quentin Gouil and Andrew Keniry, 2019）
Publications
Gouil Q , Keniry A . Latest techniques to study DNA methylation. Essays in Biochemistry, 2019.
Scott, Gigante, Quentin, et al. Using long-read sequencing to detect imprinted DNA methylation. Nucleic Acids Research, 2019.
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